KEGG   NETWORK: N00353
Entry
N00353                      Network                                

Name
HPV E6 to PTEN-PIP3-AKT signaling pathway
Definition
E6 -| SLC9A3R1 -> PTEN
  Expanded
K21807 -| 9368 -> 5728
Class
nt06114 PI3K signaling (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
9368  SLC9A3R1; SLC9A3 regulator 1
5728  PTEN; phosphatase and tensin homolog
Perturbant
K21807 (E6)  E6; HPV protein E6
Reference
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
  Authors
Accardi R, Rubino R, Scalise M, Gheit T, Shahzad N, Thomas M, Banks L, Indiveri C, Sylla BS, Cardone RA, Reshkin SJ, Tommasino M
  Title
E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1.
  Journal
J Virol 85:8208-16 (2011)
DOI:10.1128/JVI.00114-11
Reference
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
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