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Entry
N00358                      Network                                

Name
HPV E6 to p21-cell cycle G1/S
Definition
(hpvE6+UBE3A) -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
(K21807+7337) -| 7157 => 1026 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06130 Cell cycle (virus)
nt06166 Human papillomavirus (HPV)
Type
Virus
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
7337  UBE3A; ubiquitin protein ligase E3A
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21807  E6; HPV protein E6
Reference
  Authors
Munger K
  Title
The role of human papillomaviruses in human cancers.
  Journal
Front Biosci 7:d641-9 (2002)
Reference
  Authors
Chocolatewala NM, Chaturvedi P
  Title
Role of human papilloma virus in the oral carcinogenesis: an Indian perspective.
  Journal
J Cancer Res Ther 5:71-7 (2009)
DOI:10.4103/0973-1482.52788
Reference
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
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