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Entry
N00362                      Network                                

Name
HPV E5 to p21-cell cycle G1/S
Definition
hpvE5 -| (CDKN1A,CDKN1B) -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
K21812 -| (1026,1027) -| ((595,894,896)+(1019,1021)) -> 5925 // 1869,1870,1871
Class
nt06130 Cell cycle (virus)
nt06166 Human papillomavirus (HPV)
Type
Virus
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21812  E5; HPV protein E5
Reference
  Authors
de Freitas AC, Coimbra EC, Leitao Mda C
  Title
Molecular targets of HPV oncoproteins: potential biomarkers for cervical carcinogenesis.
  Journal
Biochim Biophys Acta 1845:91-103 (2014)
DOI:10.1016/j.bbcan.2013.12.004
Reference
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
Reference
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:8892872
  Authors
Tsao YP, Li LY, Tsai TC, Chen SL
  Title
Human papillomavirus type 11 and 16 E5 represses p21(WafI/SdiI/CipI) gene expression in fibroblasts and keratinocytes.
  Journal
J Virol 70:7535-9 (1996)
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