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Entry
N00363                      Network                                

Name
Antigen processing and presentation by MHC class I molecules
Definition
TAP1/2 -- TAPBP -- (PDIA3+CALR) -> (MHCI+B2M)
  Expanded
(6890,6891) -- 6892 -- (2923+811) -> ((3105,3106,3107,3133,3134,3135)+567)
Class
nt06229 MHC presentation
nt06129 MHC presentation (viruses)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04612  Antigen processing and presentation
Gene
6890  TAP1; transporter 1, ATP binding cassette subfamily B member
6891  TAP2; transporter 2, ATP binding cassette subfamily B member
6892  TAPBP; TAP binding protein
2923  PDIA3; protein disulfide isomerase family A member 3
811  CALR; calreticulin
3105  HLA-A; major histocompatibility complex, class I, A
3106  HLA-B; major histocompatibility complex, class I, B
3107  HLA-C; major histocompatibility complex, class I, C
3133  HLA-E; major histocompatibility complex, class I, E
3134  HLA-F; major histocompatibility complex, class I, F
3135  HLA-G; major histocompatibility complex, class I, G
567  B2M; beta-2-microglobulin
Reference
  Authors
Vyas JM, Van der Veen AG, Ploegh HL
  Title
The known unknowns of antigen processing and presentation.
  Journal
Nat Rev Immunol 8:607-18 (2008)
DOI:10.1038/nri2368
Reference
  Authors
Loch S, Tampe R
  Title
Viral evasion of the MHC class I antigen-processing machinery.
  Journal
Pflugers Arch 451:409-17 (2005)
DOI:10.1007/s00424-005-1420-8
Reference
  Authors
Sironi M, Cagliani R, Forni D, Clerici M
  Title
Evolutionary insights into host-pathogen interactions from mammalian sequence data.
  Journal
Nat Rev Genet 16:224-36 (2015)
DOI:10.1038/nrg3905
Reference
  Authors
Andersen MH, Schrama D, Thor Straten P, Becker JC
  Title
Cytotoxic T cells.
  Journal
J Invest Dermatol 126:32-41 (2006)
DOI:10.1038/sj.jid.5700001
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