KEGG   NETWORK: N00377Help
Entry
N00377                      Network                                

Name
HPV E6 to IFN signaling pathway
Definition
hpvE6 -| TYK2 -> (STAT1+STAT2+IRF9) => (EIF2AK2,OASL,MX1,ISG15)
  Expanded
K21807 -| 7297 -> (6772+6773+10379) => (5610,8638,4599,9636)
Class
nt06122 IFN signaling (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
7297  TYK2; tyrosine kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
8638  OASL; 2'-5'-oligoadenylate synthetase like
4599  MX1; MX dynamin like GTPase 1
9636  ISG15; ISG15 ubiquitin-like modifier
Perturbant
K21807  E6; HPV protein E6
Reference
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
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