KEGG   NETWORK: N00383
Entry
N00383                      Network                                

Name
HPV E6 to intrinsic apoptotic pathway
Definition
(E6+UBE3A) -| BAK1
  Expanded
(K21807+7337) -| 578
Class
nt06131 Apoptosis (viruses and bacteria)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
7337  UBE3A; ubiquitin protein ligase E3A
578  BAK1; BCL2 antagonist/killer 1
Perturbant
K21807 (E6)  E6; HPV protein E6
Reference
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
  Authors
Yim EK, Park JS
  Title
The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.
  Journal
Cancer Res Treat 37:319-24 (2005)
DOI:10.4143/crt.2005.37.6.319
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