KEGG   NETWORK: N00390Help
Entry
N00390                      Network                                

Name
EGF-EGFR-PI3K-NFKB signaling pathway
Definition
EGF -> EGFR -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
  Expanded
1950 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06214 PI3K signaling
nt06114 PI3K signaling (virus)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS, Workman P
  Title
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises.
  Journal
Curr Opin Pharmacol 8:393-412 (2008)
DOI:10.1016/j.coph.2008.08.004
Reference
  Authors
Li F, Zhang J, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Kumar AP, Ahn KS, Sethi G
  Title
NF-kappaB in cancer therapy.
  Journal
Arch Toxicol 89:711-31 (2015)
DOI:10.1007/s00204-015-1470-4
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