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Entry
N00393                      Network                                

Name
ITGA/B-RhoA signaling pathway
Definition
FN1 -> (ITGA+ITGB) -> SRC -> ARHGAP35 -| RHOA
  Expanded
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> 6714 -> 2909 -| 387
Class
nt06135 Cytoskeletal regulation (virus)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04510  Focal adhesion
Gene
2335  FN1; fibronectin 1
3672  ITGA1; integrin subunit alpha 1
3673  ITGA2; integrin subunit alpha 2
3674  ITGA2B; integrin subunit alpha 2b
3675  ITGA3; integrin subunit alpha 3
3676  ITGA4; integrin subunit alpha 4
3678  ITGA5; integrin subunit alpha 5
3679  ITGA7; integrin subunit alpha 7
8516  ITGA8; integrin subunit alpha 8
3680  ITGA9; integrin subunit alpha 9
8515  ITGA10; integrin subunit alpha 10
22801  ITGA11; integrin subunit alpha 11
3685  ITGAV; integrin subunit alpha V
3688  ITGB1; integrin subunit beta 1
3690  ITGB3; integrin subunit beta 3
3691  ITGB4; integrin subunit beta 4
3693  ITGB5; integrin subunit beta 5
3694  ITGB6; integrin subunit beta 6
3695  ITGB7; integrin subunit beta 7
3696  ITGB8; integrin subunit beta 8
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2909  ARHGAP35; Rho GTPase activating protein 35
387  RHOA; ras homolog family member A
Reference
  Authors
Arthur WT, Petch LA, Burridge K
  Title
Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism.
  Journal
Curr Biol 10:719-22 (2000)
DOI:10.1016/S0960-9822(00)00537-6
Reference
  Authors
Arthur WT, Burridge K
  Title
RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity.
  Journal
Mol Biol Cell 12:2711-20 (2001)
DOI:10.1091/mbc.12.9.2711
Reference
  Authors
Balanis N, Yoshigi M, Wendt MK, Schiemann WP, Carlin CR
  Title
beta3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.
  Journal
Mol Biol Cell 22:4288-301 (2011)
DOI:10.1091/mbc.E10-08-0700
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