KEGG   NETWORK: N00394Help
Entry
N00394                      Network                                

Name
HCMV gH to ITGA/B-RhoA signaling pathway
Definition
hcmvUL75 -> (ITGAV+ITGB3) -> SRC -> RAC -| RHOA
  Expanded
K22777 -> (3685+3690) -> 6714 -> (5879,5880,5881) -| 387
Class
nt06135 Cytoskeletal regulation (virus)
nt06167 Human cytomegalovirus (HCMV)
Type
Virus
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
3685  ITGAV; integrin subunit alpha V
3690  ITGB3; integrin subunit beta 3
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
387  RHOA; ras homolog family member A
Perturbant
K22777  gH; envelope glycoprotein H
Reference
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
  Authors
Wang X, Huang DY, Huong SM, Huang ES
  Title
Integrin alphavbeta3 is a coreceptor for human cytomegalovirus.
  Journal
Nat Med 11:515-21 (2005)
DOI:10.1038/nm1236
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