KEGG   NETWORK: N00395
Entry
N00395                      Network                                

Name
cGAS-STING signaling pathway
Definition
CGAS -> cGAMP -> TMEM173 -> TBK1 -> IRF3 => (IFNA,IFNB)
  Expanded
115004 -> C20640 -> 340061 -> 29110 -> 3661 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456)
Class
nt06134 CGAS-STING signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04623  Cytosolic DNA-sensing pathway
Gene
115004  CGAS; cyclic GMP-AMP synthase
340061  TMEM173; transmembrane protein 173
29110  TBK1; TANK binding kinase 1
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Metabolite
C20640  Cyclic GMP-AMP
Reference
  Authors
Ma Z, Damania B
  Title
The cGAS-STING Defense Pathway and Its Counteraction by Viruses.
  Journal
Cell Host Microbe 19:150-8 (2016)
DOI:10.1016/j.chom.2016.01.010
Reference
  Authors
Lam E, Stein S, Falck-Pedersen E
  Title
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.
  Journal
J Virol 88:974-81 (2014)
DOI:10.1128/JVI.02702-13
Reference
  Authors
Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ
  Title
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
  Journal
Science 347:aaa2630 (2015)
DOI:10.1126/science.aaa2630
Reference
  Authors
Chen Q, Sun L, Chen ZJ
  Title
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
  Journal
Nat Immunol 17:1142-9 (2016)
DOI:10.1038/ni.3558
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