Entry |
|
Name |
cGAS-STING signaling pathway
|
Definition |
CGAS -> cGAMP -> TMEM173 -> TBK1 -> IRF3 => (IFNA,IFNB) |
Expanded |
115004 -> C20640 -> 340061 -> 29110 -> 3661 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456) |
Class |
nt06134 CGAS-STING signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
|
Type |
Reference
|
Pathway |
|
Gene |
115004 | CGAS; cyclic GMP-AMP synthase |
340061 | TMEM173; transmembrane protein 173 |
29110 | TBK1; TANK binding kinase 1 |
3661 | IRF3; interferon regulatory factor 3 |
3439 | IFNA1; interferon alpha 1 |
3440 | IFNA2; interferon alpha 2 |
3441 | IFNA4; interferon alpha 4 |
3442 | IFNA5; interferon alpha 5 |
3443 | IFNA6; interferon alpha 6 |
3444 | IFNA7; interferon alpha 7 |
3445 | IFNA8; interferon alpha 8 |
3446 | IFNA10; interferon alpha 10 |
3447 | IFNA13; interferon alpha 13 |
3448 | IFNA14; interferon alpha 14 |
3449 | IFNA16; interferon alpha 16 |
3451 | IFNA17; interferon alpha 17 |
3452 | IFNA21; interferon alpha 21 |
3456 | IFNB1; interferon beta 1 |
|
Metabolite |
|
Reference |
|
Authors |
Ma Z, Damania B |
Title |
The cGAS-STING Defense Pathway and Its Counteraction by Viruses. |
Journal |
|
Reference |
|
Authors |
Lam E, Stein S, Falck-Pedersen E |
Title |
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. |
Journal |
|
Reference |
|
Authors |
Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ |
Title |
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. |
Journal |
|
Reference |
|
Authors |
Chen Q, Sun L, Chen ZJ |
Title |
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. |
Journal |
|
LinkDB |
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