KEGG   NETWORK: N00396Help
Entry
N00396                      Network                                

Name
HCMV UL82 to cGAS-STING signaling pathway
Definition
hcmvUL82 -| TMEM173 -> TBK1 -> IRF3 => (IFNA,IFNB)
  Expanded
K22779 -| 340061 -> 29110 -> 3661 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456)
Class
nt06134 CGAS-STING signaling (viruses and bacteria)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
340061  TMEM173; transmembrane protein 173
29110  TBK1; TANK binding kinase 1
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K22779  UL82; tegument protein pp71
Reference
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
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