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Entry
N00397                      Network                                

Name
HCMV UL26 to NFKB signaling pathway
Definition
hcmvUL26 -| IKK -> NFKBIA -> NFKB
  Expanded
K22780 -| (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06123 TNF signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K22780  UL26; tegument protein UL26
Reference
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
  Authors
Mathers C, Schafer X, Martinez-Sobrido L, Munger J
  Title
The human cytomegalovirus UL26 protein antagonizes NF-kappaB activation.
  Journal
J Virol 88:14289-300 (2014)
DOI:10.1128/JVI.02552-14
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