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Entry
N00402                      Network                                

Name
HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway
Definition
hcmvUS28 -> GNAQ -> PLCB -> IP3 -> Ca2+ -> CALM -- CN -> NFAT => (CXCL8,PTGS2)
  Expanded
K22781 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776) => (3576,5743)
Class
nt06124 Chemokine signaling (virus)
nt06167 Human cytomegalovirus (HCMV)
Type
Virus
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T cells 1
4773  NFATC2; nuclear factor of activated T cells 2
4775  NFATC3; nuclear factor of activated T cells 3
4776  NFATC4; nuclear factor of activated T cells 4
3576  CXCL8; C-X-C motif chemokine ligand 8
5743  PTGS2; prostaglandin-endoperoxide synthase 2
Perturbant
K22781  US28; envelope protein US28
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
  Authors
Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, Feng P
  Title
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase.
  Journal
PLoS Pathog 11:e1004768 (2015)
DOI:10.1371/journal.ppat.1004768
Reference
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
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