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Entry
N00403                      Network                                

Name
CX3CR1-GNAI-AC-PKA signaling pathway
Definition
CX3CL1 -> CX3CR1 -> GNAI -| ADCY -> cAMP -> PKA
  Expanded
6376 -> 1524 -> (2770,2771,2773) -| (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6376  CX3CL1; C-X3-C motif chemokine ligand 1
1524  CX3CR1; C-X3-C motif chemokine receptor 1
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Lee M, Lee Y, Song J, Lee J, Chang SY
  Title
Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease.
  Journal
Immune Netw 18:e5 (2018)
DOI:10.4110/in.2018.18.e5
Reference
  Authors
Oh DY, Olefsky JM
  Title
G protein-coupled receptors as targets for anti-diabetic therapeutics.
  Journal
Nat Rev Drug Discov 15:161-72 (2016)
DOI:10.1038/nrd.2015.4
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