| Entry |
|
|---|
| Name |
HCMV US28 to GNAI-AC-PKA signaling pathway
|
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| Definition |
US28 -> (GNAI,GNAO) -| ADCY -> cAMP -> PKA |
|---|
| Expanded |
K22781 -> (2770,2771,2773,2775) -| (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) |
|---|
| Class |
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06167 Human cytomegalovirus (HCMV)
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
| hsa05163 | Human cytomegalovirus infection |
|
|---|
| Disease |
| H00368 | Cytomegalovirus infection |
|
|---|
| Gene |
| 2770 | GNAI1; G protein subunit alpha i1 |
| 2771 | GNAI2; G protein subunit alpha i2 |
| 2773 | GNAI3; G protein subunit alpha i3 |
| 2775 | GNAO1; G protein subunit alpha o1 |
| 107 | ADCY1; adenylate cyclase 1 |
| 108 | ADCY2; adenylate cyclase 2 |
| 109 | ADCY3; adenylate cyclase 3 |
| 196883 | ADCY4; adenylate cyclase 4 |
| 111 | ADCY5; adenylate cyclase 5 |
| 112 | ADCY6; adenylate cyclase 6 |
| 113 | ADCY7; adenylate cyclase 7 |
| 114 | ADCY8; adenylate cyclase 8 |
| 115 | ADCY9; adenylate cyclase 9 |
| 5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
| 5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
| 5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
|
|---|
| Perturbant |
| K22781 (US28) | US28; HCMV envelope protein US28 |
|
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| Metabolite |
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| Reference |
|
|---|
| Authors |
Couty JP, Gershengorn MC |
|---|
| Title |
G-protein-coupled receptors encoded by human herpesviruses. |
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| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Lee S, Chung YH, Lee C |
|---|
| Title |
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection. |
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| Journal |
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| LinkDB |
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