NETWORK: N00404
Entry
N00404 Network
Name
HCMV US28 to GNAI-AC-PKA signaling pathway
Definition
hcmvUS28 -> (GNAI,
GNAO) -| ADCY -> cAMP -> PKA
Expanded
K22781 -> (2770,
2771,
2773,
2775) -| (107,
108,
109,
196883,
111,
112,
113,
114,
115) -> C00575 -> (5566+5567+5568)
Class
nt06124
Chemokine signaling (viruses)
nt06167
Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163
Human cytomegalovirus infection
Disease
H00368
Cytomegalovirus infection
Gene
2770
GNAI1; G protein subunit alpha i1
2771
GNAI2; G protein subunit alpha i2
2773
GNAI3; G protein subunit alpha i3
2775
GNAO1; G protein subunit alpha o1
107
ADCY1; adenylate cyclase 1
108
ADCY2; adenylate cyclase 2
109
ADCY3; adenylate cyclase 3
196883
ADCY4; adenylate cyclase 4
111
ADCY5; adenylate cyclase 5
112
ADCY6; adenylate cyclase 6
113
ADCY7; adenylate cyclase 7
114
ADCY8; adenylate cyclase 8
115
ADCY9; adenylate cyclase 9
5566
PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567
PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568
PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Perturbant
K22781
US28; envelope protein US28
Metabolite
C00575
3',5'-Cyclic AMP
Reference
PMID:
15990176
Authors
Couty JP, Gershengorn MC
Title
G-protein-coupled receptors encoded by human herpesviruses.
Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:
10.1016/j.tips.2005.06.004
Reference
PMID:
28035083
Authors
Lee S, Chung YH, Lee C
Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:
10.4062/biomolther.2016.208
LinkDB
DBGET
integrated database retrieval system
