KEGG   NETWORK: N00405Help
Entry
N00405                      Network                                

Name
CXCR4-GNA12/13-Rho signaling pathway
Definition
CXCL12 -> CXCR4 -> GNA12/13 -> (ARHGEF12,ARHGEF1) -> RHOA -> ROCK1/2
  Expanded
6387 -> 7852 -> (2768,10672) -> (23365,9138) -> 387 -> (6093,9475)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04810  Regulation of actin cytoskeleton
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2768  GNA12; G protein subunit alpha 12
10672  GNA13; G protein subunit alpha 13
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12
9138  ARHGEF1; Rho guanine nucleotide exchange factor 1
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
Reference
  Authors
Juneja J, Casey PJ
  Title
Role of G12 proteins in oncogenesis and metastasis.
  Journal
Br J Pharmacol 158:32-40 (2009)
DOI:10.1111/j.1476-5381.2009.00180.x
Reference
  Authors
Tan W, Martin D, Gutkind JS
  Title
The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.
  Journal
J Biol Chem 281:39542-9 (2006)
DOI:10.1074/jbc.M609062200
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