KEGG   NETWORK: N00407
Entry
N00407                      Network                                

Name
HCMV UL33 to GNAQ-PLCB/G-calcineurin signaling pathway
Definition
UL33 -> (GNAQ,GNA11) -> PLCB
  Expanded
K22782 -> (2776,2767) -> (23236,5330,5331,5332)
Class
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
Perturbant
K22782 (UL33)  UL33; Cytomegalovirus G-protein coupled receptor UL33
Reference
  Authors
van Cleef KW, Smit MJ, Bruggeman CA, Vink C
  Title
Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines.
  Journal
J Clin Virol 35:343-8 (2006)
DOI:10.1016/j.jcv.2005.10.013
Reference
  Authors
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ
  Title
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
  Journal
J Biol Chem 278:50010-23 (2003)
DOI:10.1074/jbc.M306530200
Reference
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
  Authors
Vink C, Beisser PS, Bruggeman CA
  Title
Molecular mimicry by cytomegaloviruses. Function of cytomegalovirus-encoded homologues of G protein-coupled receptors, MHC class I heavy chains and chemokines.
  Journal
Intervirology 42:342-9 (1999)
DOI:10.1159/000053970
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
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