KEGG   NETWORK: N00408
Entry
N00408                      Network                                

Name
LPAR-GNB/G-Rho signaling pathway
Definition
LPA -> LPAR -> GNB/G -> RHOA
  Expanded
C00681 -> (1902,9170,23566,2846,57121) -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> 387
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Gene
1902  LPAR1; lysophosphatidic acid receptor 1
9170  LPAR2; lysophosphatidic acid receptor 2
23566  LPAR3; lysophosphatidic acid receptor 3
2846  LPAR4; lysophosphatidic acid receptor 4
57121  LPAR5; lysophosphatidic acid receptor 5
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
387  RHOA; ras homolog family member A
Metabolite
C00681  1-Acyl-sn-glycerol 3-phosphate
Reference
  Authors
Niu J, Profirovic J, Pan H, Vaiskunaite R, Voyno-Yasenetskaya T
  Title
G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
  Journal
Circ Res 93:848-56 (2003)
DOI:10.1161/01.RES.0000097607.14733.0C
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