KEGG   NETWORK: N00409Help
Entry
N00409                      Network                                

Name
HCMV UL33 to GNB/G-Rho signaling pathway
Definition
hcmvUL33 -> GNB/G -> RHOA -> MAP2K6 -> p38 -> CREB
  Expanded
K22782 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> 387 -> 5608 -> (5600,6300,5603,1432) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
387  RHOA; ras homolog family member A
5608  MAP2K6; mitogen-activated protein kinase kinase 6
5600  MAPK11; mitogen-activated protein kinase 11
6300  MAPK12; mitogen-activated protein kinase 12
5603  MAPK13; mitogen-activated protein kinase 13
1432  MAPK14; mitogen-activated protein kinase 14
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
Perturbant
K22782  UL33; G-protein coupled receptor UL33
Reference
  Authors
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ
  Title
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
  Journal
J Biol Chem 278:50010-23 (2003)
DOI:10.1074/jbc.M306530200
Reference
  Authors
Yamauchi J, Tsujimoto G, Kaziro Y, Itoh H
  Title
Parallel regulation of mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 in Gq-signaling cascade.
  Journal
J Biol Chem 276:23362-72 (2001)
DOI:10.1074/jbc.M011752200
Reference
  Authors
De Cesare D, Fimia GM, Sassone-Corsi P
  Title
Signaling routes to CREM and CREB: plasticity in transcriptional activation.
  Journal
Trends Biochem Sci 24:281-5 (1999)
DOI:10.1016/S0968-0004(99)01414-0
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
LinkDB All DBs

DBGET integrated database retrieval system