KEGG   NETWORK: N00410
Entry
N00410                      Network                                

Name
DRD1-GNAS-AC-PKA signaling pathway
Definition
DA -> DRD1 -> GNAS -> ADCY5 -> cAMP -> PKA -> CREB
  Expanded
C03758 -> 1812 -> 2778 -> 111 -> C00575 -> (5566+5567+5568) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04728  Dopaminergic synapse
Gene
1812  DRD1; dopamine receptor D1
2778  GNAS; GNAS complex locus
111  ADCY5; adenylate cyclase 5
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
Metabolite
C03758  Dopamine
C00575  3',5'-Cyclic AMP
Reference
  Authors
Nishi A, Kuroiwa M, Shuto T
  Title
Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons.
  Journal
Front Neuroanat 5:43 (2011)
DOI:10.3389/fnana.2011.00043
Reference
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
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