| Entry |
|
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| Name |
HCMV UL33 to GNAS-AC-PKA signaling pathway
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| Definition |
hcmvUL33 -> GNAS -> ADCY -> cAMP -> PKA -> CREB |
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| Expanded |
K22782 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) |
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| Class |
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
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| Type |
Pathogen
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| Pathway |
| hsa05163 | Human cytomegalovirus infection |
|
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| Disease |
| H00368 | Cytomegalovirus infection |
|
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| Gene |
| 2778 | GNAS; GNAS complex locus |
| 107 | ADCY1; adenylate cyclase 1 |
| 108 | ADCY2; adenylate cyclase 2 |
| 109 | ADCY3; adenylate cyclase 3 |
| 196883 | ADCY4; adenylate cyclase 4 |
| 111 | ADCY5; adenylate cyclase 5 |
| 112 | ADCY6; adenylate cyclase 6 |
| 113 | ADCY7; adenylate cyclase 7 |
| 114 | ADCY8; adenylate cyclase 8 |
| 115 | ADCY9; adenylate cyclase 9 |
| 5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
| 5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
| 5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
| 10488 | CREB3; cAMP responsive element binding protein 3 |
| 1385 | CREB1; cAMP responsive element binding protein 1 |
| 1386 | ATF2; activating transcription factor 2 |
| 1388 | ATF6B; activating transcription factor 6 beta |
| 148327 | CREB3L4; cAMP responsive element binding protein 3 like 4 |
| 468 | ATF4; activating transcription factor 4 |
| 64764 | CREB3L2; cAMP responsive element binding protein 3 like 2 |
| 84699 | CREB3L3; cAMP responsive element binding protein 3 like 3 |
| 90993 | CREB3L1; cAMP responsive element binding protein 3 like 1 |
| 9586 | CREB5; cAMP responsive element binding protein 5 |
|
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| Perturbant |
| K22782 | UL33; G-protein coupled receptor UL33 |
|
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| Reference |
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| Authors |
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ |
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| Title |
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes. |
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| Journal |
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| Reference |
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| Authors |
van Cleef KW, Smit MJ, Bruggeman CA, Vink C |
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| Title |
Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines. |
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| Journal |
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| Reference |
|
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| Authors |
Couty JP, Gershengorn MC |
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| Title |
G-protein-coupled receptors encoded by human herpesviruses. |
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| Journal |
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| LinkDB |
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