NETWORK: N00411
Help
Entry
N00411 Network
Name
HCMV UL33 to GNAS-AC-PKA signaling pathway
Definition
UL33 -> GNAS -> ADCY -> cAMP -> PKA -> CREB
Expanded
K22782 -> 2778 -> (107,
108,
109,
196883,
111,
112,
113,
114,
115) -> C00575 -> (5566+5567+5568) -> (10488,
1385,
1386,
1388,
148327,
468,
64764,
84699,
90993,
9586)
Class
nt06124
Chemokine signaling (viruses)
nt06167
Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163
Human cytomegalovirus infection
Disease
H00368
Cytomegalovirus infection
Gene
2778
GNAS; GNAS complex locus
107
ADCY1; adenylate cyclase 1
108
ADCY2; adenylate cyclase 2
109
ADCY3; adenylate cyclase 3
196883
ADCY4; adenylate cyclase 4
111
ADCY5; adenylate cyclase 5
112
ADCY6; adenylate cyclase 6
113
ADCY7; adenylate cyclase 7
114
ADCY8; adenylate cyclase 8
115
ADCY9; adenylate cyclase 9
5566
PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567
PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568
PRKACG; protein kinase cAMP-activated catalytic subunit gamma
10488
CREB3; cAMP responsive element binding protein 3
1385
CREB1; cAMP responsive element binding protein 1
1386
ATF2; activating transcription factor 2
1388
ATF6B; activating transcription factor 6 beta
148327
CREB3L4; cAMP responsive element binding protein 3 like 4
468
ATF4; activating transcription factor 4
64764
CREB3L2; cAMP responsive element binding protein 3 like 2
84699
CREB3L3; cAMP responsive element binding protein 3 like 3
90993
CREB3L1; cAMP responsive element binding protein 3 like 1
9586
CREB5; cAMP responsive element binding protein 5
Perturbant
K22782
(UL33)
UL33; Cytomegalovirus G-protein coupled receptor UL33
Metabolite
C00575
3',5'-Cyclic AMP
Reference
PMID:
14522997
Authors
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ
Title
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
Journal
J Biol Chem 278:50010-23 (2003)
DOI:
10.1074/jbc.M306530200
Reference
PMID:
16406796
Authors
van Cleef KW, Smit MJ, Bruggeman CA, Vink C
Title
Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines.
Journal
J Clin Virol 35:343-8 (2006)
DOI:
10.1016/j.jcv.2005.10.013
Reference
PMID:
15990176
Authors
Couty JP, Gershengorn MC
Title
G-protein-coupled receptors encoded by human herpesviruses.
Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:
10.1016/j.tips.2005.06.004
LinkDB
All DBs
DBGET
integrated database retrieval system