KEGG   NETWORK: N00413
Entry
N00413                      Network                                

Name
CXCR4-GNB/G-PLCB-PKC signaling pathway
Definition
CXCL12 -> CXCR4 -> GNB/G -> PLCB -> (Ca2+,DAG) -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)
  Expanded
6387 -> 7852 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (23236,5330,5331,5332) -> (C00076,C00165) -> (5578,5579,5582) -> 2185 -> (5747+9564+1398+5829)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
2185  PTK2B; protein tyrosine kinase 2 beta
5747  PTK2; protein tyrosine kinase 2
9564  BCAR1; BCAR1, Cas family scaffold protein
1398  CRK; CRK proto-oncogene, adaptor protein
5829  PXN; paxillin
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
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