KEGG   NETWORK: N00416
Entry
N00416                      Network                                

Name
HCMV vIL10 to IL10-JAK-STAT signaling pathway
Definition
vIL10 -> IL10R -> JAK1 -> STAT3
  Expanded
K21533 -> (3587+3588) -> 3716 -> 6774
Class
nt06119 JAK-STAT signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00368  Cytomegalovirus infection
Gene
3587  IL10RA; interleukin 10 receptor subunit alpha
3588  IL10RB; interleukin 10 receptor subunit beta
3716  JAK1; Janus kinase 1
6774  STAT3; signal transducer and activator of transcription 3
Perturbant
K21533 (IL-10)  vIL10; EBV viral interleukin 10
Reference
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
  Authors
Jenkins C, Garcia W, Godwin MJ, Spencer JV, Stern JL, Abendroth A, Slobedman B
  Title
Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection.
  Journal
J Virol 82:3736-50 (2008)
DOI:10.1128/JVI.02173-07
Reference
  Authors
Spencer JV, Lockridge KM, Barry PA, Lin G, Tsang M, Penfold ME, Schall TJ
  Title
Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10.
  Journal
J Virol 76:1285-92 (2002)
DOI:10.1128/JVI.76.3.1285-1292.2002
Reference
  Authors
Magel GD (ed).
  Title
Herpesviridae -A look into this unique family of viruses-
  Journal
IntechOpen (2012)
DOI:10.5772/1207
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