KEGG   NETWORK: N00427
Entry
N00427                      Network                                

Name
HCMV vCXCL to CXCR-GNB/G-PI3K-AKT signaling pathway
Definition
vCXCL1 -> CXCR2
  Expanded
K21046 -> 3579
Class
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00368  Cytomegalovirus infection
Gene
3579  CXCR2; C-X-C motif chemokine receptor 2
Perturbant
K21046 (vCXCL1)  UL146; HCMV chemokine vCXCL1
Reference
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
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