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Entry
N00428                      Network                                

Name
CCR5-GNB/G-PLCB/G-PKC signaling pathway
Definition
CCL5 -> CCR5 -> GNB/G -> PLCB -> (Ca2+,DAG) -> PKC
  Expanded
6352 -> 1234 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (23236,5330,5331,5332) -> (C00076,C00165) -> 5578,5579,5582
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6352  CCL5; C-C motif chemokine ligand 5
1234  CCR5; C-C motif chemokine receptor 5 (gene/pseudogene)
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Shideman CR, Hu S, Peterson PK, Thayer SA
  Title
CCL5 evokes calcium signals in microglia through a kinase-, phosphoinositide-, and nucleotide-dependent mechanism.
  Journal
J Neurosci Res 83:1471-84 (2006)
DOI:10.1002/jnr.20839
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Reference
  Authors
Kawakami T, Xiao W
  Title
Phospholipase C-beta in immune cells.
  Journal
Adv Biol Regul 53:249-57 (2013)
DOI:10.1016/j.jbior.2013.08.001
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