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Entry
N00430                      Network                                

Name
CXCR4-GNAI-PI3K-BAD signaling pathway
Definition
CXCL12 -> CXCR4 -> GNAI -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
6387 -> 7852 -> (2770,2771,2773) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06124 Chemokine signaling (virus)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Teicher BA, Fricker SP
  Title
CXCL12 (SDF-1)/CXCR4 pathway in cancer.
  Journal
Clin Cancer Res 16:2927-31 (2010)
DOI:10.1158/1078-0432.CCR-09-2329
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