KEGG   NETWORK: N00432Help
Entry
N00432                      Network                                

Name
HIV gp120 to CXCR4-GNAQ-PLCB/G-calcineurin
Definition
hivEnv -> (CXCR4,CCR5) -> GNAQ -> PLCG -> IP3 -> Ca2+ -> CALM -- CN -> NFAT
  Expanded
K19287 -> (7852,1234) -> 2776 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06124 Chemokine signaling (virus)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Virus
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
7852  CXCR4; C-X-C motif chemokine receptor 4
1234  CCR5; C-C motif chemokine receptor 5 (gene/pseudogene)
2776  GNAQ; G protein subunit alpha q
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T cells 1
4773  NFATC2; nuclear factor of activated T cells 2
4775  NFATC3; nuclear factor of activated T cells 3
4776  NFATC4; nuclear factor of activated T cells 4
Perturbant
K19287  gp160; envelope glycoprotein gp160
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
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