KEGG   NETWORK: N00433Help
Entry
N00433                      Network                                

Name
CXCR4-GNB/G-RAC signaling pathway
Definition
CXCL12 -> CXCR4 -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL
  Expanded
6387 -> 7852 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (5879,5880,5881) -> 5058 -> 3984 -> (1072,1073)
Class
nt06124 Chemokine signaling (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
5058  PAK1; p21 (RAC1) activated kinase 1
3984  LIMK1; LIM domain kinase 1
1072  CFL1; cofilin 1
1073  CFL2; cofilin 2
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Nishita M, Aizawa H, Mizuno K
  Title
Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis.
  Journal
Mol Cell Biol 22:774-83 (2002)
DOI:10.1128/MCB.22.3.774-783.2002
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