KEGG   NETWORK: N00434
Entry
N00434                      Network                                

Name
HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
Definition
Env -> (CXCR4,CCR5) -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL
  Expanded
K19287 -> (7852,1234) -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (5879,5880,5881) -> 5058 -> 3984 -> (1072,1073)
Class
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
7852  CXCR4; C-X-C motif chemokine receptor 4
1234  CCR5; C-C motif chemokine receptor 5 (gene/pseudogene)
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
5058  PAK1; p21 (RAC1) activated kinase 1
3984  LIMK1; LIM domain kinase 1
1072  CFL1; cofilin 1
1073  CFL2; cofilin 2
Perturbant
K19287 (Env)  gp160; HIV-1 envelope glycoprotein gp160
Reference
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
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