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Entry
N00435                      Network                                

Name
TLR2/4-NFKB signaling pathway
Definition
(TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B)
  Expanded
(7097,7099) -> (114609+4615) -> (51135+3654) -> (7189+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970) => (7124,3569,3592,3593)
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (virus)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06169 Measles virus (MV)
nt06162 Hepatitis B virus (HBV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
7097  TLR2; toll like receptor 2
7099  TLR4; toll like receptor 4
114609  TIRAP; TIR domain containing adaptor protein
4615  MYD88; MYD88, innate immune signal transduction adaptor
51135  IRAK4; interleukin 1 receptor associated kinase 4
3654  IRAK1; interleukin 1 receptor associated kinase 1
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
3592  IL12A; interleukin 12A
3593  IL12B; interleukin 12B
Reference
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
  Authors
O'Neill LA, Golenbock D, Bowie AG
  Title
The history of Toll-like receptors - redefining innate immunity.
  Journal
Nat Rev Immunol 13:453-60 (2013)
DOI:10.1038/nri3446
Reference
  Authors
Yang L, Seki E
  Title
Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms.
  Journal
Front Physiol 3:138 (2012)
DOI:10.3389/fphys.2012.00138
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