KEGG   NETWORK: N00437Help
Entry
N00437                      Network                                

Name
HIV Vpu to TLR2/4-NFKB signaling pathway
Definition
hivVpu -| NFKB => (TNF,IFNA,IFNB1)
  Expanded
K22890 -| (4790+5970) => (7124,3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456)
Class
nt06121 TLR signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K22890  vpu; protein Vpu
Reference
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
  Authors
Bour S, Perrin C, Akari H, Strebel K
  Title
The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.
  Journal
J Biol Chem 276:15920-8 (2001)
DOI:10.1074/jbc.M010533200
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