KEGG   NETWORK: N00440Help
Entry
N00440                      Network                                

Name
HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
Definition
(hivVpu,hivVif,hivVpr) -| IRF3 => (IFNA,IFNB1,APOBEC3,SAMHD1,TRIM5,BST2)
  Expanded
(K22890,K22892,K22202) -| 3661 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456,100913187,140564,164668,200315,200316,27350,60489,9582,25939,85363,684)
Class
nt06134 CGAS-STING signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
100913187  APOBEC3A_B; APOBEC3A and APOBEC3B deletion hybrid
140564  APOBEC3D; apolipoprotein B mRNA editing enzyme catalytic subunit 3D
164668  APOBEC3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H
200315  APOBEC3A; apolipoprotein B mRNA editing enzyme catalytic subunit 3A
200316  APOBEC3F; apolipoprotein B mRNA editing enzyme catalytic subunit 3F
27350  APOBEC3C; apolipoprotein B mRNA editing enzyme catalytic subunit 3C
60489  APOBEC3G; apolipoprotein B mRNA editing enzyme catalytic subunit 3G
9582  APOBEC3B; apolipoprotein B mRNA editing enzyme catalytic subunit 3B
25939  SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
85363  TRIM5; tripartite motif containing 5
684  BST2; bone marrow stromal cell antigen 2
Perturbant
K22890  vpu; protein Vpu
K22892  vif; virion infectivity factor
K22202  vpr; virus protein R
Reference
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
  Authors
Park SY, Waheed AA, Zhang ZR, Freed EO, Bonifacino JS
  Title
HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor.
  Journal
J Biol Chem 289:35102-10 (2014)
DOI:10.1074/jbc.M114.597062
Reference
  Authors
Doehle BP, Chang K, Rustagi A, McNevin J, McElrath MJ, Gale M Jr
  Title
Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism.
  Journal
J Virol 86:8367-74 (2012)
DOI:10.1128/JVI.00423-12
Reference
  Authors
Okumura A, Alce T, Lubyova B, Ezelle H, Strebel K, Pitha PM
  Title
HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation.
  Journal
Virology 373:85-97 (2008)
DOI:10.1016/j.virol.2007.10.042
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