KEGG   NETWORK: N00443
Entry
N00443                      Network                                

Name
HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
Definition
(Vpr,Nef,Tat) -> NFKB
  Expanded
(K22202,K22891,K19258) -> (4790+5970)
Class
nt06123 TNF signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K22202 (Vpr)  vpr; HIV-1 virus protein R
K22891 (Nef)  nef; HIV-1 protein Nef
K19258 (Tat)  tat; HIV-1 protein Tat
Reference
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
DOI:10.1016/j.it.2007.10.008
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