KEGG   NETWORK: N00448
Entry
N00448                      Network                                

Name
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
(Tat,Nef) -> FASLG -> FAS
  Expanded
(K19258,K22891) -> 356 -> 355
Class
nt06131 Apoptosis (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
356  FASLG; Fas ligand
355  FAS; Fas cell surface death receptor
Perturbant
K19258 (Tat)  tat; HIV-1 protein Tat
K22891 (Nef)  nef; HIV-1 protein Nef
Reference
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
DOI:10.2174/1874357920130621001
Reference
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
DOI:10.1038/cddis.2010.77
Reference
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
Reference
  Authors
Xu XN, Laffert B, Screaton GR, Kraft M, Wolf D, Kolanus W, Mongkolsapay J, McMichael AJ, Baur AS
  Title
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.
  Journal
J Exp Med 189:1489-96 (1999)
DOI:10.1084/jem.189.9.1489
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