Entry |
|
Name |
HIV Vpr to intrinsic apoptotic pathway
|
Definition |
Vpr -> BCL2 -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3 |
Expanded |
K22202 -> 596 -| (581,578) -> 54205 -- 317 -> 842 -> 836 |
Class |
nt06131 Apoptosis (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
|
Type |
Pathogen
|
Pathway |
hsa05170 | Human immunodeficiency virus 1 infection |
|
Disease |
|
Gene |
596 | BCL2; BCL2, apoptosis regulator |
581 | BAX; BCL2 associated X, apoptosis regulator |
578 | BAK1; BCL2 antagonist/killer 1 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Perturbant |
K22202 (Vpr) | vpr; HIV-1 virus protein R |
|
Reference |
|
Authors |
Cummins NW, Badley AD |
Title |
Mechanisms of HIV-associated lymphocyte apoptosis: 2010. |
Journal |
|
Reference |
|
Authors |
Gougeon ML |
Title |
Apoptosis as an HIV strategy to escape immune attack. |
Journal |
|
LinkDB |
|