| Entry |
|
|---|
| Name |
HIV Vpr to intrinsic apoptotic pathway
|
|---|
| Definition |
Vpr -> BCL2 -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3 |
|---|
| Expanded |
K22202 -> 596 -| (581,578) -> 54205 -- 317 -> 842 -> 836 |
|---|
| Class |
nt06131 Apoptosis (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
| hsa05170 | Human immunodeficiency virus 1 infection |
|
|---|
| Disease |
|
|---|
| Gene |
| 596 | BCL2; BCL2, apoptosis regulator |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
|
|---|
| Perturbant |
| K22202 (Vpr) | vpr; HIV-1 virus protein R |
|
|---|
| Reference |
|
|---|
| Authors |
Cummins NW, Badley AD |
|---|
| Title |
Mechanisms of HIV-associated lymphocyte apoptosis: 2010. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Gougeon ML |
|---|
| Title |
Apoptosis as an HIV strategy to escape immune attack. |
|---|
| Journal |
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|---|
| LinkDB |
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|---|
