KEGG   NETWORK: N00454Help
Entry
N00454                      Network                                

Name
HIV Vpr to intrinsic apoptotic pathway
Definition
hivVpr -| BAX -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
K22202 -| 581 -> 54205 -- 317 -> 842 -> (836,840)
Class
nt06131 Apoptosis (virus)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Virus
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
581  BAX; BCL2 associated X, apoptosis regulator
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Perturbant
K22202  vpr; virus protein R
Reference
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
DOI:10.1038/cddis.2010.77
Reference
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
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