KEGG   NETWORK: N00460Help
Entry
N00460                      Network                                

Name
HIV Vpr to WEE1-cell cycle G2M
Definition
hivVpr -> WEE1 -| (CCNB+CDK1)
  Expanded
K22202 -> 7465 -| ((891,9133,85417)+983)
Class
nt06130 Cell cycle (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
7465  WEE1; WEE1 G2 checkpoint kinase
891  CCNB1; cyclin B1
9133  CCNB2; cyclin B2
85417  CCNB3; cyclin B3
983  CDK1; cyclin dependent kinase 1
Perturbant
K22202  vpr; virus protein R
Reference
  Authors
Bagga S, Bouchard MJ
  Title
Cell cycle regulation during viral infection.
  Journal
Methods Mol Biol 1170:165-227 (2014)
DOI:10.1007/978-1-4939-0888-2_10
Reference
  Authors
Kamata M, Watanabe N, Nagaoka Y, Chen IS
  Title
Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2.
  Journal
J Virol 82:5672-82 (2008)
DOI:10.1128/JVI.01330-07
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