KEGG   NETWORK: N00466Help
Entry
N00466                      Network                                

Name
EBV BPLF1 to TLR2/4-NFKB signaling pathway
Definition
ebvBPLF1 -| (TRAF6+TAK1+(TAB1,TAB2)) -> IKK -> NFKBIA -> NFKB => (TNF,IL6)
  Expanded
K22972 -| (7189+6885+(10454,23118)) -> (1147+3551+8517) -> 4792 -> (4790+5970) => (7124,3569)
Class
nt06121 TLR signaling (virus)
nt06165 Epstein-Barr virus (EBV)
Type
Virus
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
Perturbant
K22972  BPLF1; HHV4 large tegment protein deneddylase
Reference
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
  Authors
Saito S, Murata T, Kanda T, Isomura H, Narita Y, Sugimoto A, Kawashima D, Tsurumi T
  Title
Epstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-kappaB signaling during productive replication.
  Journal
J Virol 87:4060-70 (2013)
DOI:10.1128/JVI.02020-12
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