KEGG   NETWORK: N00470Help
Entry
N00470                      Network                                

Name
EBV BGLF4 to RIG-I-like receptor signaling pathway
Definition
ebvBGLF4 -| IRF3 => (IFNA,IFNB1)
  Expanded
K19455 -| 3661 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456)
Class
nt06133 RIG-I signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Perturbant
K19455  BGLF4; serine/threonine-protein kinase BGLF4
Reference
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
  Authors
Wang JT, Doong SL, Teng SC, Lee CP, Tsai CH, Chen MR
  Title
Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway.
  Journal
J Virol 83:1856-69 (2009)
DOI:10.1128/JVI.01099-08
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