KEGG   NETWORK: N00472
Entry
N00472                      Network                                

Name
EBV LMP1 to IFN signaling pathway
Definition
LMP1 -| TYK2
  Expanded
K19459 -| 7297
Class
nt06122 IFN signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
7297  TYK2; tyrosine kinase 2
Perturbant
K19459 (LMP1)  LMP1; EBV latent membrane protein 1
Reference
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
  Authors
Geiger TR, Martin JM
  Title
The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.
  Journal
J Virol 80:11638-50 (2006)
DOI:10.1128/JVI.01570-06
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