KEGG   NETWORK: N00472Help
Entry
N00472                      Network                                

Name
EBV LMP1 to IFN signaling pathway
Definition
ebvLMP1 -| TYK2 -> (STAT1+STAT2+IRF9) => (EIF2AK2,OAS,IRF7,CXCL10,ISG15)
  Expanded
K19459 -| 7297 -> (6772+6773+10379) => (5610,4938,4939,4940,3665,3627,9636)
Class
nt06122 IFN signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
7297  TYK2; tyrosine kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
3665  IRF7; interferon regulatory factor 7
3627  CXCL10; C-X-C motif chemokine ligand 10
9636  ISG15; ISG15 ubiquitin-like modifier
Perturbant
K19459  LMP1; latent membrane protein 1
Reference
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
  Authors
Geiger TR, Martin JM
  Title
The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.
  Journal
J Virol 80:11638-50 (2006)
DOI:10.1128/JVI.01570-06
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