KEGG   NETWORK: N00473
Entry
N00473                      Network                                

Name
EBV BGLF4 to IFN signaling pathway
Definition
BGLF4 -| (STAT1+STAT2+IRF9)
  Expanded
K19455 -| (6772+6773+10379)
Class
nt06122 IFN signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
Perturbant
K19455 (BGLF4)  BGLF4; EBV serine/threonine-protein kinase BGLF4
Reference
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
  Authors
Wang JT, Doong SL, Teng SC, Lee CP, Tsai CH, Chen MR
  Title
Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway.
  Journal
J Virol 83:1856-69 (2009)
DOI:10.1128/JVI.01099-08
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