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Entry
N00481                      Network                                

Name
EBV BZLF1 to p53-mediated transcription
Definition
ebvBZLF1 -| TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
  Expanded
K19462 -| 7157 => (1026,1647,4616,10912,581,578,1643,51426)
Class
nt06165 Epstein-Barr virus (EBV)
Type
Virus
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1647  GADD45A; growth arrest and DNA damage inducible alpha
4616  GADD45B; growth arrest and DNA damage inducible beta
10912  GADD45G; growth arrest and DNA damage inducible gamma
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
1643  DDB2; damage specific DNA binding protein 2
51426  POLK; DNA polymerase kappa
Perturbant
K19462  BZLF1; trans-activator protein BZLF1
Reference
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
  Authors
Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T
  Title
Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.
  Journal
Virology 388:204-11 (2009)
DOI:10.1016/j.virol.2009.03.017
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