KEGG   NETWORK: N00486
Entry
N00486                      Network                                

Name
EBV LMP1 to Jak-STAT signaling pathway
Definition
LMP1 -> JAK3 -> (STAT3+STAT1)
  Expanded
K19459 -> 3718 -> (6774+6772)
Class
nt06119 JAK-STAT signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
3718  JAK3; Janus kinase 3
6774  STAT3; signal transducer and activator of transcription 3
6772  STAT1; signal transducer and activator of transcription 1
Perturbant
K19459 (LMP1)  LMP1; EBV latent membrane protein 1
Reference
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
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