KEGG   NETWORK: N00488Help
Entry
N00488                      Network                                

Name
EBV LMP2A to BCR signaling pathway
Definition
ebvLMP2A -- NEDD4 -| (LYN,SYK) -> (BTK,BLNK) -> PLCG2 -> IP3 -> Ca2+
  Expanded
K19460 -- 4734 -| (4067,6850) -> (695,29760) -> 5336 -> C01245 -> C00076
Class
nt06120 Calcium signaling (virus)
nt06165 Epstein-Barr virus (EBV)
Type
Virus
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
4734  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
4067  LYN; LYN proto-oncogene, Src family tyrosine kinase
6850  SYK; spleen associated tyrosine kinase
695  BTK; Bruton tyrosine kinase
29760  BLNK; B cell linker
5336  PLCG2; phospholipase C gamma 2
Perturbant
K19460  LMP2; latent membrane protein 2
Reference
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
Reference
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
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