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Entry
N00494                      Network                                

Name
HTLV-1 Tax to p16-cell cycle G1/S
Definition
htlvTAX -| CDKN2A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
K21857 -| 1029 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06130 Cell cycle (virus)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Virus
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21857  tax; protein Tax-1
Reference
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
  Authors
Hasui K, Wang J, Tanaka Y, Izumo S, Eizuru Y, Matsuyama T
  Title
Development of ultra-super sensitive immunohistochemistry and its application to the etiological study of adult T-cell leukemia/lymphoma.
  Journal
Acta Histochem Cytochem 45:83-106 (2012)
DOI:10.1267/ahc.11034
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