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Entry
N00495                      Network                                

Name
HTLV-1 Tax to p15-cell cycle G1/S
Definition
htlvTAX -| CDKN2B -| (CCND+CDK4/6)
  Expanded
K21857 -| 1030 -| ((595,894,896)+(1019,1021))
Class
nt06230 Cell cycle G1/S
nt06130 Cell cycle (virus)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Virus
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
1030  CDKN2B; cyclin dependent kinase inhibitor 2B
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
Perturbant
K21857  tax; protein Tax-1
Reference
  Authors
Suzuki T, Narita T, Uchida-Toita M, Yoshida M
  Title
Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms.
  Journal
Virology 259:384-91 (1999)
DOI:10.1006/viro.1999.9760
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
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