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Entry
N00496                      Network                                

Name
MDM2-p21-Cell cycle G1/S
Definition
CDKN2A -| MDM2 -| TP53 => CDKN1A -| (CDK2+CCNE) -> RB1 // E2F
  Expanded
1029 -| 4193 -| 7157 => 1026 -| (1017+(898,9134)) -> 5925 // (1869,1870,1871)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
4193  MDM2; MDM2 proto-oncogene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1017  CDK2; cyclin dependent kinase 2
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
  Authors
Sheppard KE, McArthur GA
  Title
The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma.
  Journal
Clin Cancer Res 19:5320-8 (2013)
DOI:10.1158/1078-0432.CCR-13-0259
Reference
  Authors
Cholewa BD, Liu X, Ahmad N
  Title
The role of polo-like kinase 1 in carcinogenesis: cause or consequence?
  Journal
Cancer Res 73:6848-55 (2013)
DOI:10.1158/0008-5472.CAN-13-2197
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