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Entry
N00498                      Network                                

Name
HTLV-1 Tax to p21-cell cycle G1/S
Definition
htlvTAX -| CDKN1A -| (CDK2+CCNE) -> RB1 // E2F
  Expanded
K21857 -| 1026 -| (1017+(898,9134)) -> 5925 // (1869,1870,1871)
Class
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Virus
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1017  CDK2; cyclin dependent kinase 2
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21857  tax; protein Tax-1
Reference
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
  Authors
Hasui K, Wang J, Tanaka Y, Izumo S, Eizuru Y, Matsuyama T
  Title
Development of ultra-super sensitive immunohistochemistry and its application to the etiological study of adult T-cell leukemia/lymphoma.
  Journal
Acta Histochem Cytochem 45:83-106 (2012)
DOI:10.1267/ahc.11034
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