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Entry
N00499                      Network                                

Name
ATR-p21-Cell cycle G2/M
Definition
(ATM,ATR) -> CHEK1 -> TP53 => CDKN1A -| (CDK1+CCNB)
  Expanded
(472,545) -> 1111 -> 7157 => 1026 -| (983+(891,9133,85417))
Class
nt06230 Cell cycle G1/S
nt06130 Cell cycle (virus)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
472  ATM; ATM serine/threonine kinase
545  ATR; ATR serine/threonine kinase
1111  CHEK1; checkpoint kinase 1
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
983  CDK1; cyclin dependent kinase 1
891  CCNB1; cyclin B1
9133  CCNB2; cyclin B2
85417  CCNB3; cyclin B3
Reference
  Authors
Shaltiel IA, Krenning L, Bruinsma W, Medema RH
  Title
The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.
  Journal
J Cell Sci 128:607-20 (2015)
DOI:10.1242/jcs.163766
Reference
  Authors
Nascimento R, Costa H, Parkhouse RM
  Title
Virus manipulation of cell cycle.
  Journal
Protoplasma 249:519-28 (2012)
DOI:10.1007/s00709-011-0327-9
Reference
  Authors
Wang Y, Ji P, Liu J, Broaddus RR, Xue F, Zhang W
  Title
Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy.
  Journal
Mol Cancer 8:8 (2009)
DOI:10.1186/1476-4598-8-8
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