KEGG   NETWORK: N00503Help
Entry
N00503                      Network                                

Name
HTLV-1 Tax to TNF-JNK signaling pathway
Definition
htlvTAX -> (MAPK8,MAPK9,MAPK10) -> JUN => MMP7
  Expanded
K21857 -> (5599,5601,5602) -> 3725 => 4316
Class
nt06223 TNF-NFKB signaling
nt06123 TNF signaling (viruses and bacteria)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
4316  MMP7; matrix metallopeptidase 7
Perturbant
K21857  tax; protein Tax-1
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
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